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Properties. Colourless small needle crystals or
light white crystal powder, flavourless, we will dissolve in water
(1:300) a little, it is easy in alcohol (1:20), chloroform,
solutions of caustic and carbonic alkalis. In the damp environment
it is hydrolyzed with formation of acetic and salicylic acids.
Action and application. Acetyl salicylic acid -
effective soothing, febrifugal, anti-inflammatory and antirheumatic
remedy. On activity it concedes sodium to salycylate a little, but
is better transferred by animals. In a stomach does not decay, in
intestines slowly turns into acetic and salicylic acid. At dogs
medicine can remove or warn bacterial endotoxic shock.
It is similar sodium to salycylate, acetilsalicylic acid has
some antikoagulyantny activity and use it for the prevention of
postoperative thromboses, at violations of brain blood circulation,
etc. It is one of strong inhibitors of biosynthesis of
prostaglandins that can play a role in the mechanism of its
anti-inflammatory action and in the braking influence on
aggregation of platelets.
Appoint acetilsalicylic acid inside at muscular and articulate
rheumatism, as febrifugal and sedative. In high doses it can
promote development of bleeding, especially at the diseases which
are followed by violation of aggregation of platelets.
Acetilsalicylic acid less than sodium salycylate, causes the
by-effects connected with malfunction of nervous system however can
lead to complications from a stomach. Its prolonged use provokes
the dispepsichesky phenomena and gastric bleedings. The last are
caused not only by rezorbtivny effect of acetilsalicylic acid
(braking of factors of fibrillation), but also its direct
irritating influence on a mucous membrane of a stomach and a
duodenum. For the purpose of elimination of this influence medicine
should be set 15-30 minutes later after feeding with the subsequent
Acetilsalicylic acid can cause allergic reactions,
bronchospasms, angioneurotic hypostases, skin reactions, etc. It is
contraindicated at stomach ulcer of a stomach and duodenum,
gastrointestinal bleedings and in the first half of pregnancy.
Doses inside: to horses of 25-50 g; to cattle of 25-75
g; to small cattle of 3-10 g; to pigs of 3-5 g; to dogs of 0,2-2 g;
to hens of 0,1-0,3 g, minks of 0,1-0,2 g.
With drinking water in a dose of 1 g on 10 kg of mass of an
animal (100 mg of acetilsalicylic acid on 1 kg of mass of an
animal) or 1 kg on 1 ton of a forage within 3-5 days.